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In the intense accessory therapy of bipolar mania(approximately 3 weeks)research studies, one of the most generally noted negative reactions linked with using Seroquel( occurrence of 5 % or greater)and observed at a price on Seroquel at the very least twice that of sugar pill were somnolence(34 %), completely dry mouth (19 % ), asthenia (10 %), irregularity (10 %), abdominal discomfort(7 %), postural hypotension(7 %), pharyngitis (6 %), and weight gain( 6 %).

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Table 10 identifies the incidence, rounded to the nearest percent, of damaging responses that took place during therapy (as much as 3 weeks) of severe mania in 2 % or even more of patients treated with Seroquel (dosages varying from 100 to 800 mg/day) utilized as complement therapy to lithium as well as divalproex where the occurrence in individuals treated with Seroquel was higher than the occurrence in placebo-treated people.

“The threat of orthostatic hypotension as well as syncope could be minimized by restricting the initial dosage to 25 mg twice daily [view Dosage as well as Administration (2.2)] A return to the previous dose in the titration routine is appropriate if hypotension happens throughout titration to the target dosage.”